In order to study the effect of clearance on the structural characteristics of the screw rotor of the twin-screw compressor and to avoid interference and wear of rotor,numerical simulation calculations were carried out for the influence of the tooth tip clearance and the inter-tooth clearance on the structural characteristics of the screw rotor in the twin-screw compressor.The results show that with the increase of the tooth tip clearance and the inter-tooth clearance,the maximum deformation of the female and male rotors shows a trend of first increasing then decreasing,but the change range is small; the maximum stress of the female and male rotors increases with the increase of the inter-tooth clearance;with the increase of the tooth tip clearance,the maximum stress of the male and female rotor tends to be unchanged; when the tooth tip clearance is greater than or equal to 0.17 mm and the inter-tooth clearance is greater than or equal to 0.33 mm,interference and wear problems due to rotor deformation can be avoided.