How to use handwheels to control the movement of each axis in the machine tool controlled by SIMOTION D435 was described. In the synchronous movement, the handwheel was the master, and the axis was the slave. The realization of this control method needed two steps: first, the hardware design of the handwheel, including the hardware connection between the handwheel and the controller and the hardware configuration of the handwheel on the software; next, the software design of the handwheel, including the use of synchronous instruction and the program design of synchronization. This control method has achieved good control effect in the debugging of the production.