The acoustic finite element analysis of DK4012 ball screw pair was carried out by using VirtualLab. Based on its transient dynamic analysis model, the sound pressure on the outer surface of the ball screw pair and the sound pressure at the field point were simulated and analyzed respectively. The acoustical characteristics of the ball screw pair noise were studied by setting up an experimental platform to verify the accuracy and rationality of the simulation model. The results show that the noise sound pressure level increases with the increase of rotational speed, and the increasing speed of the noise level is accelerated, and the higher low frequency sound pressure is in the double frequency of the ball pass frequency and the ball pass frequency, and the maximum peak value is on the ball pass frequency. The main sound source of the bar pair is the periodic collision between the ball and the backwarder.