The NC program format requirements of SKY5L14075 five-axle linkage CNC machine tool were taken as the research object, the key technology of post-processing files conforming to the SKY5L14075 machine tool requirements based on UG software was introduced in detail. Taking the impeller as an example, the actual NC machining was performed to verify the correctness of the NC program after post-processing. It is proved by practice that the machined impeller meets the specified accuracy requirements, and the correctness of the post-processing file based on UG software is verified, it embodies the machined feasibility of using SKY5L14075 five-axle CNC machine tool based on UG, providing reference for using post-processing five-axle linkage CNC machine tool of other control system.