In order to predict tooth contact state for drive bridge hypoid gears, the tooth flank mismatch analysis method was proposed. The HFT grinding mathematical model and conjugate meshing mathematical model of hypoid gears were established, and the pinion base tooth flank equation which was fully conjugated with the gear tooth flank was derived, and the tooth flank deviations between the pinion actual tooth flank and pinion base tooth flank were calculated with numerical method, and the tooth flank mismatch topology was constructed by graphical expression. The tooth flank mismatch analysis was executed for a pair of hypoid gear with HFT grinding, and the rolling test experiment result was in accordance with the simulation result. This indicates that the proposed tooth flank mismatch analysis method can be used to predict the tooth contact state, and it provides theoretical guidance for tooth contact area correction