According to the requirements of parts processing technology and production cycle, an intelligent manufacturing production line was designed, which mainly included three CNC machining centers, ABB industrial robot, the seventh axis of industrial robot, loading and unloading conveying line and grinding station. Industrial robot was used for loading, unloading and grinding machining; the structure design of the production line, the construction and working process of the seventh axis, the working process of the industrial robot, the application of PROFINET bus and the design of the control system were described in detail. The practice shows that the usage of the bus decreases the design difficulty of the production line greatly, full automation processing is realized, and the production cycle and quality requirements are met. It improves the economic benefits