The machine tool body is the core components of machine tool, and has a great significance and influence to improve the machining accuracy of machine tool. By taking a research object of the dedicated boring machine tool for the water tanks processing of pump truck, the three dimensional (3D) model of machine tool body and related parts were built by Solidworks software, then the entity models were imported into ANSYS Workbench for statics and dynamics analysis. By comparison of the machine tool body with different ribs form, the appropriate form of ribs layout was determined. Thus the structure optimized analysis of machine tool body with selected the ribs form is done, and the structure of machine tool body is determined ultimately.