The high-speed milling is one of key technologies in aeronautical manufacturing. Based on 7050-T7451 aluminum alloy, the influences of milling parameters on milling force and milling temperature were investigated using the orthogonal test method. The results show that the x-direction milling force is greater than the y-direction milling force in the selected parameter range. Variation of milling depth has the most significant effect on milling force. Milling force increases as the feed per tooth and milling depth increases, while decreases with increasing of milling speed. Variation of feed per tooth has the most significant effect on milling temperature, the milling temperature increases with the increase of the milling parameters.