In order to improve the machining ability in drilling of TC4 Titanium alloy, TC4 Titanium milling finite element model (FEM) is established with the finite element analysis (FEA) software AdvantEdge. Temperature distribution on the workpiece and the tool were analyzed, and the rule of effect of drilling parameters on drilling force and drilling temperature during processing were obtained. The results show that the highest temperature appears on the chip in drilling of TC4 Titanium alloy. With increasing of spindle speed and feed rate, the drilling force is increased, and with increasing of drill bit diameter, the drilling force is decreased. Drilling temperatures are increased along with the increasing of spindle speed, feed rate and drill bit diameter.