Aimed at the problem that there are pick-up position deviations in the process of industrial robots transporting workpieces, by taking the MOTOMAN-SV3X robot as the object, a industrial robot handling system was researched and developed, which has the functions of visual positioning and position adjustment. The system was introduced of constitutions, workflow, and robot pose, and a method of solving the problem of pickup position deviation was proposed. It provides an automated and flexible application program for industrial robot handling technology, thereby improves handling precision and efficiency.