It is extremely popular that three dimension modeling and dynamics analysis are carried out with both Pro/E and ADAMS. But the problems of data transmission are existed between Pro/E and ADAMS. This paper aims at studying the neutral files supported by Pro/E and ADAMS, such as*.stp,*.slp,*.stl,*.igs,*.x_t,*.obj. Finally an example of five-axis linkage milling head is presented to carry out the comparative analysis for the neutral files. The research shows that: *.xt and *.obj files are relatively superior to other neutral files in the data transmission between Pro/E and ADAMS.