Vibration fatigue reliability of AMT actuator is one of the most significant performance of AMT. For accurate and efficient analysis and evaluation of AMT actuator vibration fatigue reliability, multi-axial multi-excitations road simulation test method for AMT actuator based on time-frequency domain error-weighted remote parameter square matrix control (RPC) was put forward. AMT actual road load spectra acquisition method was established and AMT actuator actual driving road load spectra were collected in Dongfeng automobile testing field. The collected load spectra were conducted with pretreatment and repeatability inspection and thus expected response signals for indoor road simulation test were obtained.AMT multi-axes road simulation test bench was designed and developed based on the AMT actuator actual road vibration load characteristics. Combined with the collected real road load spectra and developed AMT actuator multi-axes road simulation test bench, load spectrum simulation iteration method based on remote parameter square matrix control with time-frequency domain error weighting coefficients 0.5 respectively succeeded in achieving accurate and efficient reproducing of AMT actuator actual driving road load spectra, therefore muti-axial multi-excitations road simulation test method for AMT actuator was established and thus provided an accurate and efficient new method for vehicle AMT actuator vibration fatigue reliability assessment.