The rigid model for tool was selected in order to study the cemented carbide tool wear when turning titanium alloy. The plastic model was selected for workpieces, and tool wear was simulated by using finite elements software in machining. Orthogonal experiment analysis was used to analyze the changes of the amount of tool wear of different cutting tool parameter in combination. The results show that the effect on tool wear quantity of the interaction of the rake angle and back angle is larger under fixed technical parameters. The change of the single parameter factors effect on the quantity of tool wear is small. The analysis results provide a reference for reducing tool wear of carbide when turning titanium alloy.