Design of off-line Programming is quite complex based on coordinate measuring machine (CMM)， especially aiming at parts without three dimensional (3D) digital model. Therefor computer aided design (CAD) based point cloud model was presented. Off-line Programming was compiled to delete the unusual points and to pick up feature points by according to the features of plane and cylinder commonly seen in parts, to edit dimensional measuring interface specification (DMIS) program for automatic measurement and to simulate test for CMM online measurement. The example verification indicates that this method is simple to CMM off-line program, and realizes automatic CMM measurement stably.