Large cutting chatter is one of the main factors to cause the defects in the process of manufacturing integral impeller. Firstly, the technology optimization of nonuniform allowance machining process of impeller blade was designed. Secondly, the vibration modal analysis and harmonic analysis of the model before and after technology optimization were carried out based on Workbench. Lastly, compared processing experiment before and after technology optimization and three dimension (3D) measuring shape were done on the surface of parts of impeller. Measurement results show the average optimization rate of suction surface of impeller is 63.8% and the average optimization rate of pressure surface is 48.8%. Results show that the technology optimization stragety has feasibility and effectiveness, which has instructive significance to the actual production of parts similar to impeller in structure.