In order to optimize the control performance of the control system of the intelligent control valve, the control algorithm is studied intensively. According to the characteristics of time varying and nonlinear of valve control cylinder pneumatic system, the parameters of proportionalintegral-differential (PID) were adjusted by fuzzy control. At the same time, in order to realize the simulation verification of fuzzy PID, the modeling process of the controlled object was simulated by using the AMESim physical graphics modeling software. Based on the analysis of specific characteristics of the controlled object for solution to conform to the particular case of a transfer function, then the application of MATLAB in the signal constraint module to optimize the routine PID parameters, in line with the control system PID three initial values were gotten. At last, combined with the MATLAB and AMESim, the fuzzy PID control algorithm simulation analysis was realized. The results show that the intelligent fuzzy PID control algorithm for high speed, small overshoot, high regulating precision, antiinterference ability strong, and steady state performance good response, the control performance is obviously better than the routine PID control, especially for control system with time varying and nonlinear characteristics.