Put forward a robot based on Modbus fieldbus control technology of automatic packaging palletizing production line, to improve logistics efficiency and enhance the packaging palletizing system intelligence and versatility. The Siemens S7-1200 programmable logical controller (PLC) sequence control operation was used to achieve automatic packaging palletizing production line material of conveying line, packaging and palletizing line. The information of shape, position and number were identified by Vision intelligent system for parts waiting for packing. Industrial robots, visual intelligent detection and upper computer were through Modbus fieldbus and PLC for information exchange to enhance packing and palletizing system of reliability and applicability. Practice has proved that the method enable the packaging palletizing production line to improve the automation degree, the allocation of resources, and system layout can be optimized, with debugging cost saving.