The simulation and cutting experiments of difficult-to-cut material GH4169 under the condition of dry cutting,conventional lubricants and MQL were described.The cutting force and temperature of GH4169 in the three ways were simulated by using ABAQUS,the method of multi-factors was used to conduct the cutting experiments.Comparing the different lubrication ways influence on cutting force and cutting temperature,the curves of the different factors were illustrated and the change of the force during the cutting process was obtained.The basic data from this research can be used or as reference in the practical applications.