Based on Teamcenter, we can compete the computer numerical control (CNC) machine and manipulator mechatronics conceptual design and the control simulation are completed, mainly including: demand analysis, mechanical design, and design automation. Based on NX MCD platform, according to the demand of the automatic updown material manipulator analysis, it was completed of function mechanism of the decomposition, and the design and definition of reuse, functional properties, as well as the simulation sequence set and growth of Programmable Logical Controller(PLC) program, completed of the automatic updown material virtual simulation of the manipulator. Practical application embodies the NX MCD platform system with more high integration, concept modeling and simulation, which can realize the advantages of reuse of knowledge, to break the existing mechanical and electrical integration of product conceptual design model, the design way of the enterprise reform, speed up the enterprise research and development, to enhance the synergy between the department has a certain practical guiding significance.