Abstract:As the presentation of German “Industrie 4.0”, the “Industrial Internet” in USA and “Made in China 2025”, intelligent manufacturing industry gets rapid development. Application of industrial robot in intelligent manufacturing will expand rapidly. On the basis of intelligent manufacturing production line,the operation,communication,control of the industrial robot were researched.An industrial robot could finish the work including precise reclaiming , discharging work, charging and unloading work of four sets of CNC machine tool through communications with external devices. The production rhythm is greatly improved and production cost is saved,and any interference will not happen.