In view of the structure and the size requirement of the guide vane and the existing processing equipment of the company,threeaxis machining process scheme of the guide vane flow passage was put forward.The technical process and its implementing of the guide vane flow passage by the PowerMill programming software were introduced,and the positioning problem during the manufacturing process was solved.The whole surface processing of the guide vane had been completed by making full use of the company’s existing equipment,and the dimension and the roughness requirement of the guide vane were effectively guaranteed.