In order to solve the problems of manual operation, high labor intensity, high production cost and low working efficiency of the gluing process of the natural rubber packaging production line,a set of hydraulic gluing device，gluing manipulator of the natural rubber packaging production line was designed. It mainly includes transmission device, clamping device and hydraulic control system. The main structural parameters were determined. At the same time, the process of the natural rubber packing production line and the automatic control process of the gluing manipulator were described. The experimental results show that the manipulator is smooth and the glue effect is good. The quality and efficiency of the manipulator are greatly improved. It is proved the design is reasonable, high in mechanical automation, and can be widely used in practical production.