Made in China 2025 has been proposed. Intelligent manufacturing has higher and higher requirements on the precision of CNC machine tools. The thermal deformation of machine tool is a prominent factor affecting the machining precision. From the angle of collecting the temperature of the machine tool and the deformation of the spindle, the collection schemes of the temperature and the deformation of the spindle were designed. The screw into the hole type and magnetic type temperature sensor were selected to measure the internal and surface temperature of heat source.The electric eddy current sensor was selected to measure the radial offset and axial elongation of the spindle. The main shaft temperature of the two processing environments of dry cutting and adding cutting fluid was collected. In conclusion, the temperature rise of spindle motor is the highest. Cutting fluid can take away a lot of heat in cutting, which effectively reduces the influence of heat in cutting on spindle.The higher the spindle speed, the greater the temperature and axial elongation.