The multipleaxis flexure hinges with multiple degrees of freedom are used in the threedimensional motion. A novel multipleaxis flexure hinge right circular elliptical hybrid multipleaxis flexure hinge was introduced. Based on the Castigliano’s second theorem, the compliance formulations of the novel multipleaxis flexure hinge were formulated. The compliance calculations and the finite element simulation were performed simultaneously for a set of examples. By contrast to the above results, the error between them is within 14%, so the correctness of the compliance formulations is indicated. By means of the compliance formulations, the effects of the geometric parameters on the compliance were analyzed. The relative compliance ratio was defined, the novel multipleaxis flexure hinge had better compliance and sensitivity to the loads than the right circular multipleaxis flexure hinge. All of the above provides a new idea for the analysis and design of the multipleaxis flexure hinges in the spatial compliant mechanisms.