Considering the influence of the distance between the liquid along radial different cylindrical layers in turbine channel and axis on the velocity of liquid particles and interaction force between blades and them, a simplified turbine fluid model is established. The axial flow coefficient and circulating coefficient of turbine were duly corrected, and turbine with twisted blades was designed. Additionally, the hydraulic performance of turbine with twisted blades and straight blades was analyzed comparatively by numerical simulation analysis, which verified the feasibility of the design method. The results show that the torque of turbine with twisted blades decrease 194%, and its hydraulic efficiency increase 105% while its pressure drop decrease 396%, comparing to turbine with straight blades. Whats more, its comprehensive hydraulic performance is improved. The research provides a theoretical basis for the design of turbine with twisted blades and is of certain guiding significance for the actual engineering.