Simulation analysis model of axial vibration drilling in vertical deep hole is established. Ultrasonic vibration drilling and ordinary drilling simulation analysis was carried out for axial force by DEFORM-3D finite element software, analysis and comparison of two sets of simulation results were carried out, and in the ultrasonic axial direction deep hole vibration drilling and ordinary drilling experiments were carried out on the stainless steel plate on the vibration drilling device. The axial force of the vibration drilling and the ordinary drilling was measured by the piezoelectric sensor. The comparison between the experimental results and the simulation results show that the deviation between simulation results and experimental results is less than 8%. The average axial force of ultrasonic vibration drilling is smaller than that of ordinary drilling, and the drilling process is stable.