In order to improve the assembly efficiency and accuracy of large and special-shaped parts，a multi-axis control system of Six degrees of freedom (6-DOF) parallel platform is designed. By controlling the expansion and contraction of six electric cylinders, the motion of the moving platform in 6-DOF in space was realized. Beifu C6015-0010 controller was selected as the control core of the whole system, and TwinCAT control was used to realize the communication between industrial control computer, motion controller and numerical control (CNC) system. The accuracy of azimuth angle, pitch angle and roll angle of the control system can be realized as ±0.01°, and the accuracy of vertical, longitudinal and lateral linear displacement is ±0.1 mm.