Lithiumion batteries are widely used in energy storage, electric energy and other fields, but there are some safety problems in the application of lithiumion batteries in the field of new energy vehicles, which will restrict the commercial application. In this paper, the authors put forward specific measures for safety factor of automobile lithiumion batteries through production of single batteries and strict quality control. The authors further studied the safety protection measures of positive material, negative material, diaphragm, electrolyte and battery shell of single lithiumion batteries. Reasonable system design and overcome the battery technology, make the use of new energy vehicles more secure.