With the rapid development of “Internet +”, the new strategy of “Intelligence +”was first put forward in the government work report in 2019.The characteristics and development status of intelligent technology in the era of “Intelligence +” were introduced.The application of “Intelligence +” in the transformation and upgrading of China’s manufacturing was elaborated and analyzed in detail from 4 aspects, such as data closedloop automatic flow optimization of resource allocation efficiency and production efficiency based on data closedloop automatic flow, digital capabilities migrating to the supply side to drive supply chain intelligence, “data + computing power + algorithm” driving the industrial brain to carry out tool revolution and decision revolution, and reconstruction of new intelligent manufacturing system.As the first driving force of “nuclear fusion”, intelligent technology and the data provide new impetus for Made in China 2025 strategy and the highquality development of China’ s economy.