As the basic component of the guide robot,the stability and reliability of the robot chassis need to be ensured.The threedimensional model of the chassis structure was built by using SolidWorks,then it was imported into ANSYS Workbench to carry out static analysis,modal analysis and harmonic response analysis.The results of static analysis show that the maximum stress of chassis is 37813 MPa,and the safety factor is 54.The strength of chassis structure meets the requirements.The natural frequencies and modes of chassis structure were obtained by modal analysis.According to the natural frequencies of chassis structure,the motor met the requirements was selected to avoid chassis resonance under the excitation of driving motor.The resonance frequency and amplitude of the frame provide a theoretical basis for the further optimization design of the chassis structure of the robot.