In order to improve the operation stability and production efficiency of CNC machine tools, a control system of the robot manufacturing cell for automatic loading and unloading workpieces was designed.The manufacturing cell structure and production process were analyzed,an automatic control scheme was designed in which SIMATIC S7-1200 PLC was taken as the controller and ProfiNet protocol was used to remote control robot and CNC machine coordination operations. The main equipment and I/O module were selected and I/O signals were allocated. The robot and PLC control program was written according to the requirements of the production process, ABB IRB120 robot and SINUMERIK 828D machining center information were interacted,and automatic loading and unloading workpieces auxiliary work during CNC machining was realized.The results show that the control system meets the requirements of CNC machining automatic loading and unloading operation, labor cost is effectively reduced, and product quality stability and production efficiency are improved