Based on practical experience and theoretical research, the authors use the finite element software ANSYS to analyze and calculate the modal analysis of the spindle guide rail system which affects the accuracy of the guide rail. The accuracy and service life of the guide rail are improved by appropriately increasing the surface hardness of the guide rail, and the static simulation of the guide rail system is performed to determine the static stiffness of the guide rail. The high stiffness performance of the guide rail is confirmed by experimental data. It is necessary to pay attention to material selection and force analysis calculation during design, and also pay attention to dust protection, lubrication and proper pretightening.