The structural characteristics and machining requirements of bone nail were analyzed.Combined with the typical instance, the machining process of bone nail based on CNC double spindle Swiss lathe was proposed. The main machine and tools layout structure of CNC double spindle Swiss lathe for bone nail machining were presented. Transmission system of driving tool, servo feeding axes and spindles were designed by using gears, ball screws and direct drive motors. Prototypes were manufactured and used on bone nail producing. The results are helpful to the application of CNC Swiss lathe on bone nail machining industry.