To study the safety and aerodynamic performance of highspeed train operation under strong wind and sand environment, based on the aerodynamic theory, the Navier-Stokes equation, and κ-ε standard turbulence model are used to calculate the continuous turbulence movement of the airflow and the DPM model has used to discretization the movement of sand particles. The EulerLagrange model is used to solve the example. The results show that the eddy strength of the leeward side of the train decreases with the increase of the sandcarrying wind speed. While near the ground on the leeward side, the train’s streamline becoming more and more irregular; In addition, the pressure of the train body will increase with the rising of the sandcarrying wind speed and decrease while the sand diameter get larger. When the sandcarrying wind speed increases, the drag, lateral force, and lift of the train increase together. With the increase of sand diameter, the lift force, lateral force, drag force and overturning moment of the train all decrease correspondingly, but they are larger than the net wind condition. The research results are valuable for designing highspeed railway lines in the region with severe wind and sand environments.