In order to solve the problem of weld crack on the compartment when compressed refuse collector is in service under actual working conditions, a frame bearing structure of the arc compartment was designed. Pro/E was used to build the 3D model of the compartment and ANSYS Workbench was used to carried out the finite element static analysis to obtain the stress distribution in the process of garbage loading and unloading; the modal analysis was carried out to determine the natural vibration frequency and the maximum deformation position of each vibration mode. A three-interval method based on the Gaussian distribution and Miner’〖KG-*2〗s rule was used to perform random fatigue analysis to determine whether the newly designed compartment structure met the service life expectation. The results show that the maximum stress is 300 MPa on the improved compartment and at most 40 MPa on the guide rail during the process of waste handling, and the overall structure meets the design requirements; with the increase of vibration frequency, the maximum deformation position of the compartment transfers from the roof to the sideboard and then to the floor. In the process of driving, the designed compartment structure can meet the actual service life expectation under the actual working conditions.