In order to avoid the pose error in offline measurement of the aspheric optical elements with large aperture and high precision,a design scheme of precise centering and leveling worktable was proposed,by which the problem of the deviation in X,Y and Z directions of aspheric mirrors in offline measurement caused by improper clamping was solved.By analyzing the relative pose error between the turntable and the aspheric surface at 6 degrees of freedom in space,and taking the least square method as the basic mathematical theory and the model parameter evaluation as the guide,an optimization model based on the least square method was established.The results show that the model has high accuracy in correcting the above error sources,and the proposed table can be used as an independent accessory to improve the machining and measuring environment of the large aperture aspheric optical elements and improve the grinding accuracy are verified.