Ground vibration can easily make machine tool exceed allowable processing or measurement deviation, thereby affecting the processing quality of the machine tool. Therefore, a new type of electrohydraulic actuator was proposed to isolate the machine tool from vibration.A machine tool active vibration isolation system was constructed,a neural network PID controller was adopted to implement effective control of the machine tool active vibration isolation system,and the control effect was simulated.The structure of the machine’ s active vibration isolation system was analyzed. The dynamic models of the electrohydraulic actuator and the machine tool of the machine’ s active vibration isolation system were established.The mathematical model of the actuator was coupled to the virtual model of the machine tool. Based on neural network and PID controller, a neural network PID controller was developed. The MATLAB was used to simulate the active vibration isolation system of the machine tool. At the same time, the calculation results of traditional PID controllers were compared and analyzed. The simulation results show that the displacement amplitude of the table and tool center under the control of the neural network PID controller is reduced by 30%~82% compared with the traditional PID controller. After the neural network PID controller is used for control, the control accuracy is higher, the vibration effect is also better. The electrohydraulic actuator using the neural network PID controller can effectively attenuate and isolate ground motion.