Taking the thread forming process of TC4 titanium alloy bolt as the research object, the influence of tangential speed, radial feed speed and friction coefficient on thread forming quality was obtained by using the ABAQUS finite element soft. The results show that the tangential speed and friction coefficient have significant influences on the thread forming quality, while the radial feed speed of the screw plate has little influence on the thread forming quality; when the tangential speed is lower than 300 mm/s, the forming quality of thread is better, and when it is higher than 300 mm/s, the forming quality of thread is worse; with the increase of friction coefficient, the forming quality of thread first becomes better and then becomes worse. Through comparative analysis, the optimal thread rolling forming process parameters of TC4 titanium alloy were determined as the tangential speed of 300 mm/s and the friction coefficient within 0.3~0.4.The conclusions obtained can provide reference for the selection of the process parameters of the TC4 titanium alloy thread forming.