In order to clarify the windproof effect of the wind fences and the distribution of the leeward side flow field of the wind fences of the Lanxin Second Line bridge, the most representative 32 m box girder structure model in Xinjiang section of the Lanxin Second Line bridge was selected. Based on the Fluent windsand twophase unsteady model and the standard κ-ε turbulence model, a qualitative simulation analysis of the overall wind field distribution characteristics of highspeed railway bridges and wind fences under wind and sand conditions was made.The results show that after setting onesided and twosided wind fences, a relatively continuous wind pressure deceleration zone will be formed on the leeward side of the wind fence; with the arrangement of onesided and twosided wind fences, the leeward side of the wind fence will be away from the bed surface, the change law of wind speed at the height of 0.4 m basically shows a trend of first decrease and then increase, and the vertical profile of wind speed at different heights is basically the same, showing a trend of first increase, then decrease and then increase.The wind speed change rule of the twosided wind fences leeward side is always smaller than the onesided wind fence; under the effect of the doublesided wind fences, as the wind speed increases, the wind speed change remains stable within 1.2 m from the bed surface of the upward lane to the height of the wind fence itself; to some extent, it will aggravate the sand accumulation above the bridge track.