In order to reduce the labor cost of warehousing logistics and improve the automation level and production efficiency of logistics enterprises,Siemens SMART 200 PLC was used as the core controller, magnetic strips were used for path guidance, and ultrasonic, photoelectric sensor and anticollision bar were used to constitute the threelevel safety protection system of the robot. Kunlun TPC7062KX embedded integrated touch screen was used as the manmachine interaction interface. The control system of the mobile robot was developed by designing control circuit, writing motion control program and editing humancomputer interaction interface. Through the system, the functions of mobile robot such as forward, backward, straight, turning, speed regulation, parking, automatic operation and manual operation can be realized. The control system is stable, reliable, easy to operate and safe, and the material transportation task can be completed well by using it.