In order to solve the problems of uneven pressure distribution and low bearing capacity, rigidity and damping performance caused by a single oil inlet of a common oil cavity of a hydrostatic guide rail, the optimal design of the hydrostatic guide was carried out. The mathematical model of the hydrostatic guide was established and the design parameters of the guide rail were obtained. The key parameters affecting the performance of the guide rail were selected and the function for optimizing the performance index was established. The combination of the design parameters of the guide rails with the optimal bearing capacity, rigidity and damping was found by combining the genetic algorithm, the Taguchi method and the grey correlation analysis method. The simulation and experimental results show that the design is feasible and effective.