Aiming at the phenomenon that cavitation is generated in a certain area of the flow field in the mechanical seal cavity, a geometric simulation model of the seal cavity was established.The cavitation phenomenon of the flow field in the mechanical seal cavity was simulated and optimized by using commercial analysis software combined with the multi-phase flow model, and the position and distribution of the cavitation in the flow field in the mechanical seal cavity were obtained. The influence of the inlet pressure and rotation speed in the flow field on the generation of cavitation were analyzed and the parameters were optimized by using Kriging interpolation method.The results show that under same initial conditions, the inlet pressure and rotation speed of different flushing fluids can promote or inhibit the generation of cavitation in the seal cavity; the combination range of the inlet pressure and rotation speed that inhibit cavitation is reduced through Kriging interpolation and error analysis.