Hydraulic pipeline is an important part of the hydraulic system of civil aircraft, and it is prone to fatigue failure under the action of cyclic pressure load. The solid model of the pipeline was established by using the 3D software SolidWorks, and the geometric model was saved as a file in X_T format, which was imported into the finite element analysis software ANSYS Workbench to obtain the finite element model of the pipeline. The model was meshed and boundary conditions were applied, and the pipeline was statically analyzed. On this basis, according to the material properties of the pipeline, the Fatigue Tool module in the Workbench was used to analyze the fatigue life of the pipeline to find out the possible location of the pipeline that was prone to failure. The research results provide reference for maintenance and structural optimization design of civil aircraft hydraulic system.