In order to reveal the dynamic characteristics of the main bearing of megawatt wind turbine under the excitation of multiple dynamic parameters, the influences of the large range movement of the space flexible mechanism and the small range deformation of the elastomer itself on the main bearing were considered, the main bearing parametric analysis was carried out, and the dynamic equation under dynamic load was numerically solved. Taking the main bearing of megawatt wind turbine as the research object, a rigid flexible multi-body contact model was established to simulate and verify the correctness and reliability of the model. The results show that by analyzing the rigid flexible multi-body contact dynamic characteristics of the main bearing, the dynamic response characteristics between the components of the main bearing during the operation of the wind turbine, the contact force variation rule of the flexible body under different working conditions and the stress danger position of the inner ring in the gust stage can be obtained. The research results provide reference for structural optimization of main bearing of wind turbine.