Taking the multi robot flexible manufacturing line based on IRB1410 as the research object, a virtual simulation production line scheme was proposed by using SolidWorks and RobotStudio. The composition and process flow of multi robot flexible manufacturing simulation production line were briefly introduced. The definition of robot flange center point, the calibration of hand coordinate system and workpiece coordinate system were introduced, and the Smart dynamic components of CNC were designed. The off-line program was compiled in the simulation production line, and the robot running situation was displayed according to the trajectory planning. The dynamic trajectory simulation result shows that the trajectory planning and programming meet the expectation. Practice has proved that the virtual simulation production line is helpful to the design, optimization and debugging of the physical production line, it provides a theoretical basis for the entity production line.