In order to improve the work performance of multiphase pump and reduce energy loss,the external characteristics and internal energy loss of multiphase pump were analyzed under different number of guide vanes.The results show that when the number of guide vanes is 10,the external characteristics of the multiphase pump are obviously worse than that when the number of guide vanes is 7 and 8,and the maximum efficiency is biased to the low flow condition;under different flow rates,when the number of guide vanes is 8,the shrinkage loss and turbulent dissipation loss in the impeller of the multiphase pump are the smallest,while the number of guide vanes has little effect on the impact loss at the inlet of the guide vane,which can be ignored;under the selected three groups of guide vanes,when the number of guide vanes is 8,the performance of the multiphase pump is the best and the energy loss in the flow channel is the smallest.