In view of the characteristics of flow pulsation and pressure pulsation of fracturing pump, a combined accumulator and pressurized cylinder fluid pulsation suppression method was proposed, and a mathematical model of fracturing pump and pulsation suppression circuit was established based on MATLAB/Simulink. The effect of the pulsation suppression method was compared and analyzed according to theory and simulation analysis.The simulation results show that the accumulator volume and precharging pressure can significantly affect the flow pulsation;when the precharging pressure is 4 MPa and the volume is 6 L, the flow rate and pressure pulsation rate decrease from 39.99% and 76.93% to 2.47% and 4.89% respectively.