In order to further improve the performance of cyclone separator,the structure of guide vane separator was multi-objective optimized.The parametric script model was constructed by using script,and the accuracy of the model was verified by bench test.Based on the global high sensitivity parameters,the structure of separator was optimized by the improved PSO algorithm which had strong search ability and fast convergence speed,and with the separation efficiency and the pressure drop as the performance objectives.The rate of parameters change,static pressure and turbulent kinetic energy before and after optimization were compared and analyzed.The optimal scheme was selected combined with the engineering requirements,and the optimal scheme was tested.The results show that the optimal parameter configurations can effectively reduce the internal turbulent motion intensity and energy loss.The efficiency of the optimal scheme is increased from the original 85.10% to 92.09%,and the pressure drop was reduced by 30.45%.