It is important for the study on the high elasticity properties and material non-linearity of rubber material through determing a reasonable constitutve model fornitrile rubber.The parameters of constitutive model directly affect the reliability of its finite element analysis.A method was proposed to determine the key parameters C10 and C01 of the Mooney-Rivilin model by experiment.The curve of stress-strain was obtained by the uniaxial compression experiments on the specimens of nitrile rubber,and it was fitted with the stress-strain relationship calculated based on the strain energy function.After a comparison with the numerical analysis and finite element simulation in ABAQUS,it verifies the correctness and reasonableness of parametersC10 and C01.The research method of Mooney-Rivilin constitutive model parameters obtained by uniaxial compression experiment provides a convenient way for the theoretical research of nitrile rubber materials in industrial environment.