Aiming at the problem of axis deflection in titanium alloy drilling process,two different drilling processes of titanium alloy based on Abaqus were simulated.The finite element model and mathematical model of drill pipe were established,and the problem of axis deflection was transformed into the problem of axial force of two different drilling modes.It is concluded that when the workpiece speed is 180 r/min to 900 r/min and the drill bit and workpiece rotate in reverse direction,the axial force will decrease with the increase of workpiece speed.With this drilling mode,16 groups test were made with the workpiece speed is 900 r/min and different bit speed and feeding.The results show that when the bit speed is 900 r/min to 1 800 r/min and the feeding is 0.02 mm/r to 0.08 mm/r,the average axial force decreases by 33.4%.Therefore,the deflection can be reduced by using this drilling method.